I would think the larger wing area with new more powerful engines should allow higher operating altitude and speed.
Variable cycle engines that allow them to operate with bypass air acting like a ramjet should allow very high speed flight, and with low drag conformal weapon positions carrying a large number of AAMs externally should allow combat persistence.
I would think that increasing speed and range with new engines, plus improving the radar and the missile carriage capacity would be useful goals.
I would think that a modified Tu-22M3M with a new layout with a fixed enlarged delta wing and variable sweep outer wing panels with the removal of the horizontal tail surfaces but the addition of the control surfaces above the air intakes like on the PAK FA might allow a radical increase in wing area, with an increase in weapons carried and new engines and an enormous new AESA radar could make for an interesting stopgap aircraft.