Of course the irony is that the west loves drones because their manned equipment is now too expensive to use, whereas Russia is using drones in jobs where their characteristics are useful... ie they are small and hard to see or they are expendable.
The west goes on about suicide drones but anti tank and anti ship and a range of air and ground launched missiles are all effectively suicide drones.
Right now drones often arrive in groups and in the future will too... I don't mean thousands... this Iranian drone system is mounted in a truck and has a dozen or so drones ready to launch per truck... which means it can be used in concentrations against certain targets.
Air defences like Russian defences can't be penetrated like Kiev forces can be penetrated at the moment... you need a lot of threats all coming at once... like HIMARS rockets and other rockets and drones and perhaps even aircraft launching HARMs all coming at once and still they shoot them down...
It is only going to get worse so a range of solutions would be useful.
152mm guns make sense because of their range and altitude capacity... they are already in service on vehicles and as truck mounted systems that already have full elevation and traverse performance.
The larger calibre gives more space for things like fuel and onboard propulsion... imagine a drone that deploys blades like that Hellfire the CIA uses to murder people and it just flys around and flies through target drones in a ramming attack... it could fly down a line of cruise missiles or incoming drones taking out as many targets as it can.
Russia is really the only country with the IADS needed to track targets across the whole battle space so you could have ground or air based sensors detecting drones or missiles or low flying aircraft that can track them and pass their target data to a centralised management system that might allow the local artillery battery to launch a volley of airburst HE frag shells to airburst in a calculated intercept box 40km away from the gun position out in the middle of no where.
As far as the drones are concerned they will be flying along and then all these airburst 152mm HE Frag shells start detonating all round them... shredding them with their fragments.
The ability to do that would also be very useful for area targets in an open field that allows the delivery of a large number of shells to land in a pattern to evenly spread their fragments over a wide area to get good coverage over a large area of soft spread out targets.
As a current example a group of Orcs in civilian cars... an artillery attack to immobilise them and do damage out in the middle of nowhere could damage the vehicles to the point where they will have to ditch their heavy equipment and run or be attacked by helicopters or other forces.